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TIP. Revista especializada en ciencias químico-biológicas
versión impresa ISSN 1405-888X
TIP vol.12 no.2 Ciudad de México dic. 2009
Artículos de revisión
Los metales como inhibidores del sistema de reparación del ADN
1 Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México. Circuito Exterior Universitrario s/n, Col. Coyoacán, C.P. 04510, México, D.F. MéxicoE-mail: emilior@biomedicas.unam.mx
Los humanos han estado en contacto con los metales desde su aparición en el planeta. De hecho no se puede pensar en la evolución humana sin pensar en el gran papel que han jugado los metales en el desarrollo humano. Algunos metales son esenciales para llevar a cabo procesos celulares, sin embargo, otros son capaces de promover una gran variedad de efectos deletéreos para la salud, incluyendo el cáncer. Las evidencias de que la inhibición de los mecanismos de reparación del ADN, es un importante paso para que se lleve a cabo la carcinogénesis inducida por los metales cobran día a día más importancia, sin embargo, es poco probable que exista un mecanismo de acción común para todos los metales debido a que presentan propiedades químicas diversas. En la presente revisión, se discutirá el papel de los metales en la inhibición de los mecanismos de reparación, poniendo énfasis en algunos mecanismos de acción propuestos como son: la inactivación de enzimas, la unión a componentes celulares, la inducción de daño al ADN, entre otros.
Palabras Clave: Dedos de zinc; metales; reparación del ADN
Humans have been in contact with metals almost since the beginning of our existence. In fact, one cannot even think on human evolution without considering the great role played by metals in mankind’s development. Some metals are essentials for cellular processes; however other metals are less beneficial, owing to their ability to promote a wide variety of deleterious health effects, including cancer. The evidence that inhibition of DNA-repair processes is an important step in metal carcinogenesis is growing; however a uniform mechanism of action for all metals is unlikely given the diverse chemical properties of each metal. In the present review, the impairment of DNA-repair by metals and the different mechanisms of metal DNA repair inhibition, such as, inactivation of enzymes, binding to cellular components, induction of DNA damage, etc, will be discussed.
Keywords: Zinc fingers; metals; DNA repair
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Recibido: 02 de Octubre de 2009; Aprobado: 23 de Noviembre de 2009
Este es un artículo publicado en acceso abierto bajo una licencia Creative Commons
