Abstract

QUINTAL-NOVELO, Carlos; TORRES-TAPIA, Luis W.; MOO-PUC, Rosa  and  PERAZA-SANCHEZ, Sergio R.. Cytotoxic Constituents from the Stem Bark of Alvaradoa amorphoides. J. Mex. Chem. Soc [online]. 2015, vol.59, n.3, pp.211-214. ISSN 1870-249X.

The chemical study of Alvaradoa amorphoides led to the isolation of four major constituents: chrysophanol (1), β-sitosterol (2), atraric acid (3), and 17-octadecen-6-ynoic acid (4). All compounds were evaluated on in vitro cytotoxic and antiproliferative assays. Atraric acid and 17-octadecen-6-ynoic acid showed cytotoxic activity. Additionally, compound 4 exhibited cytotoxic activity showing a certain degree of selectivity against cancer cell lines.

Keywords : Alvaradoa amorphoides; cytotoxic activity; antiproliferative activity; acetylenic compound.

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