Abstract

ROSALES-LAGARDE, Alejandra; MARTINEZ-ALCALA, Claudia Isabel; RODRIGUEZ-TORRES, Erika Elizabeth  and  CUBERO-REGO, Lourdes. Arousals and periodic leg movements during sleep stages and mild cognitive impairment in older adults: a preliminary study. CienciaUAT [online]. 2023, vol.18, n.1, pp.41-62.  Epub Sep 29, 2023. ISSN 2007-7858.  https://doi.org/10.29059/cienciauat.v18i1.1749.

Sleep fragmentation may be associated with several diseases, including dementia. In this sense, sleep fragmentation, indicated by the rates of arousals and/or periodic leg movements (PLM), could be an early marker of Mild Cognitive Impairment (MCI), a syndromic stage prior to dementia. Therefore, the objective of this study was to compare the index of PLM with that of arousals and correlate both indexes in people with MCI and without MCI during all sleep stages. In 9 participants (3 control women and 3 women with MCI; and 3 men with MCI) (ages: 69.1 ± 5; years of education: 8 ± 2), one night of polysomnography was performed. Hourly rates of arousals and PLM were scored from each sleep stage. Analyses were performed within and between PLM and arousals for each group. Significant differences and a positive correlation were found between the arousal and the PLM rates for the group with MCI during the whole night. Knowledge of the prevalence and the association of both phenomena may contribute to a more careful and thorough evaluation of older adults at risk of developing MCI and/or dementia.

Keywords : mild cognitive impairment; sleep; polysomnography; periodic leg movements; arousals.

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