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Revista alergia México
On-line version ISSN 2448-9190
Abstract
SANTAMARIA, Luis and SANCHEZ, Jorge. Long-term efficacy of omalizumab in patients with conventional treatment-resistant vernal keratoconjunctivitis. Rev. alerg. Méx. [online]. 2018, vol.65, n.2, pp.192-196. ISSN 2448-9190. https://doi.org/10.29262/ram.v65i2.2927.
Background:
In vernal keratoconjunctivitis, traditional treatments are sometimes insufficient for symptom control; the results with omalizumab are promising in resistant cases.
Case report:
15-year-old female adolescent with vernal keratoconjunctivitis who had received multiple ophthalmic treatments, immunotherapy and systemic steroids with no clinical response. She attended a clinical immunology and allergy department where she was started on omalizumab 225 mg every 2 weeks. After 6 months, she showed a decrease in pruritus and photophobia; two years later, both papillae and Horner-Trantas dots had disappeared. She remained symptom-free, and the use of ophthalmic drugs was therefore reduced. The patient missed omalizumab application on 4 occasions; however, symptoms recurred, and the papillae reappeared, but remitted upon drug re-initiation.
Conclusion:
There is a temporal relationship between omalizumab administration and ocular symptom control, with evidence of relapse upon discontinuation.
Keywords : Allergy; Atopy; Conjunctivitis; Vernal keratoconjunctivitis; Omalizumab.