Abstract

ARELLANES-GARCIA, Lourdes; PADILLA-AGUILAR, Gonzalo; NAVARRO-LOPEZ, Patricia  and  ESPINOZA-MARTINEZ, Cynthia. Efficacy of prednisolone and rimexolone in HLA-B27 positive patients with acute anterior uveitis. Gac. Méd. Méx [online]. 2005, vol.141, n.5, pp.363-366. ISSN 2696-1288.

Purpose: To compare the efficacy and safety of prednisolone acetate 1 % vs. rimexolone 1 % ophthalmic suspension in the treatment of acute anterior uveitis (AAU) in HLA-B27+ patients. Methods: Sixty-eight AAU HLA-B27+ patients were randomly selected for treatment with prednisolone acetate 1% or Rimexolone 1%. All patients showed mild to moderate anterior chamber inflammation. This was a prospective, randomized, double blind, clinical trial. Results: There was no statistically significant difference between both groups when anterior chamber cells were measured. In the rimexolone group, flare diminished since the first week. In both groups the intraocular pressure (IOP) raised since the first week; the increase washighly significant in the rimexolone group. Final intraocular pressure was higher in the prednisolone group. Conclusion: Rimexolone 1 % is as effective as prednisolone acetate 1% in the treatment of mild to moderate AAU HLA B27+. IOP increased in both groups, but this variation was not clinically significant.

Keywords : Anterior uveitis; flare; cells; rimexolone; prednisolone acetate; HLA-B27; intraocular pressure.