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Gaceta médica de México
On-line version ISSN 2696-1288Print version ISSN 0016-3813
Abstract
PEREZ-CASTANEDA, Ana I. et al. Sensitivity and specificity of increased pulse pressure as a diagnostic test for K/DOQI III-b. Gac. Méd. Méx [online]. 2020, vol.156, n.5, pp.432-437. Epub May 27, 2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.20005623.
Introduction:
Increased pulse pressure (IPP) is associated an estimated glomerular filtration ≤ 60/mL/min/1.73 m2; thus, it can be useful as a diagnostic test to identify people with K/DOQI stage III-b chronic kidney disease (CKD).
Objective:
To determine the usefulness of IPP as a diagnostic test for K/DOQI stage III-b CKD.
Method:
Diagnostic test study that included adult patients without comorbidities, registered in the Health Workers Cohort. The CKD-EPI formula was used to calculate glomerular filtration. Pulse pressure was determined by subtracting diastolic from systolic blood pressure. Sensitivity, specificity, positive predictive value, negative predictive value and prevalence were calculated using standard formulas. A ROC curve was generated to determine the area under the curve.
Results:
A total of 6,215 patients were included. An IPP ≥ 50 mmHg was observed to have a sensitivity of 74 %, specificity of 70 %, positive predictive value of 1 %, negative predictive value of 100 % and a prevalence of 1 %. The inflection point in the ROC curve to identify K/DOQI III-b CKD was 0.71.
Conclusion:
An IPP ≥ 50 mmHg is useful as a diagnostic test to identify people with K/DOQI stage III-b CKD.
Keywords : Pulse pressure; Diagnostic test; Glomerular filtration; K/DOQI III-b.