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Gaceta médica de México
On-line version ISSN 2696-1288Print version ISSN 0016-3813
Abstract
FLORES-RAMIREZ, Anaisa G.; IBARRA-REYNOSO, Lorena del R. and GARAY-SEVILLA, María Eugenia. Soluble receptor for advanced glycation end products and lipid profile ratio as cardiovascular risk markers in children with obesity. Gac. Méd. Méx [online]. 2023, vol.159, n.1, pp.10-16. Epub May 02, 2023. ISSN 2696-1288. https://doi.org/10.24875/gmm.22000200.
Introduction:
Obesity has been shown to be associated with low levels of soluble receptor for advanced glycation end products (sRAGE).
Objective:
To evaluate the levels of sRAGE and its association with the lipid index in children with obesity.
Methods:
Cross-sectional study of children with obesity aged between six and 11 years. Anthropometric measurements, glucose, lipid profile, insulin and sRAGE were evaluated; body mass index, total cholesterol/high-density cholesterol (TC/HDL-C), triglycerides/glucose (TG/glucose), and triglycerides/HDL-C (TG-HDL-C) ratios and HOMA-IR were also calculated.
Results:
Eighty children were studied, among which 50% were males and 50% females. Females had higher values for waist circumference, HOMA-IR, and TG/HDL-C and TG/glucose ratios. No significant differences were found for sRAGE. When the variables were compared according to TG/HDL-C ratio tertiles, higher TC/HDL, TG/glucose, and sRAGE values were found at upper tertile. A significant correlation was observed between sRAGE and HOMA-IR (p < 0.03) in males, and between sRAGE and TG/HDL-C (p < 0.01) and TG/glucose ratios (p < 0.008) in females.
Conclusions:
The female gender showed more cardiovascular risk factors and higher sRAGE at TG/HDL-C upper tertile. Further studies are required to test the possible predictive effect of higher risk for developing metabolic and cardiovascular complications.
Keywords : Children; Obesity; TG/HDL-C ratio; sRAGE.