Abstract

ACOSTA ALTAMIRANO, Gustavo et al. Free radicals and mechanisms of tissue damage in diabetes mellitus. Rev. Fac. Med. (Méx.) [online]. 2011, vol.54, n.3, pp.46-53. ISSN 2448-4865.

Diabetes mellitus (DM) is a chronic-degenerative disease with a high incidence and prevalence around the world. Chronic hyperglycemia, a feature of diabetes, induces a higher production of superoxide free radicals, which play a major role in the mechanisms of tissue damage responsible for the clinical complications of DM: advanced glycosylation and activation of sorbitol, hexosamines, and protein kinase C pathways. Although different drugs that inhibit the damaging pathways have been developed, their actual benefit in diabetic patients has not been proved yet. Therefore, adequate glycemia control is still the fundamental factor to prevent or delay tissue damage.

Keywords : Diabetes mellitus; hyperglycemia; free radicals; oxidative stress; diabetic complications; antioxidants; reactive oxygen species.

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