Abstract

ITAMI-SORDO, Ma. Eréndira; JIMENEZ-NIETO, René  and  DE HARO, Roberto. Vascular factors involved in pre-eclampsia. Rev. Fac. Med. (Méx.) [online]. 2013, vol.56, n.2, pp.18-24. ISSN 2448-4865.

Preeclampsia is a disease that only affects pregnant women and is characterized by hypertension and proteinuria with or without edema after 20 weeks' gestation. Although many hypotheses have been postulated to explain its pathogenicity, some of them have recently concurred that the cause may be an altered placental circulation which causes hypoxia to the fetus and systemic endothelium dysfunction to the mother by reducing the factors promoting adequate endothelial functioning. Soluble FMS-like receptor 1 (sFlt-1) and en-doglin (sEng) have been associated to a decrease of Vascular endothelial growth factor (VEGF) and Transforming growth factor (TGF) in mother's plasma, respectively; thus contributing to a deficient persufion of the fetus and to maternal disturbances, leading to hypertension and proteinuria. Some substances like antibodies against angiotensin II may trigger the release of such angiogenic factors. The assessment of sFlt-1 and sEng in pregnant women plasma might be used to to detect those women who will develop preeclampsia.

Keywords : Preeclampsia; woman; pregnant.

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