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Revista de la Facultad de Medicina (México)
On-line version ISSN 2448-4865Print version ISSN 0026-1742
Abstract
GUEVARA VALMANA, Osvaldo Iván; VENZOR CASTELLANOS, Juan Pablo and MARTINEZ JIMENEZ, Angélica. Rapidly Progressive Dementia, on a Creutzfeldt-Jakob Case Report. Rev. Fac. Med. (Méx.) [online]. 2020, vol.63, n.6, pp.31-37. Epub Mar 05, 2021. ISSN 2448-4865. https://doi.org/10.22201/fm.24484865e.2020.63.6.04.
The Creutzfeldt-Jakob disease is a neurodegenerative, neuroselective and fatal entity, that is not usually reported in Mexico. We present a 40-year-old male patient who presents the onset of this illness, with short-term memory disorder, depressive episodes and emotional lability with a tendency to irritability. He also presents space disorientation, decreased strength of the left and lateral hemibody drive in the ipsilateral walk, and insomnia, for which he is admitted to the hospital during 40 days for diagnostic approach. Several studies were carried out during his hospital stay, the most relevant for the diagnosis: a magnetic resonance which presented "cortical ribboning" and hyperintensities in the nuclei of the base, both diagnosis highly suggested the pathology. The positive results to protein 14-3-3 reaffirmed the diagnosis. After 15 months of the onset of neurological symptoms, the patient presented symptoms of pneumonia, which lead to the hospitalization. During his stay, he presented a pulmonary abscess and rapid progressive dementia. The patient died in the hospital by a pulmonary sepsis 18 months after the onset of symptoms. No necropsy was performed, following the current standards for the disease management.
Keywords : Creutzfeldt-Jakob disease; prion diseases; rapidly progressive dementia.