Abstract

ESCALONA-SARABIA, Ana Luisa  and  JUAREZ, Esmeralda. Eicosanoids as regulators of inflammation and immunology process during pulmonary tuberculosis. Neumol. cir. torax [online]. 2022, vol.81, n.2, pp.109-120.  Epub Aug 28, 2023. ISSN 0028-3746.  https://doi.org/10.35366/108497.

Human tuberculosis (TB) is a public health problem. Although it is a curable disease, the actual treatment protocol is long and difficult to maintain. Because of the limit progress of new therapies during the latest years, host direct therapies have taken more interest, being one of the proposals the intervention on the eicosanoids’ metabolic route. Eicosanoids are local chemical mediators that promote or limit inflammation progress. During TB, hyperinflammation generates damage to the pulmonary parenchyma with the subsequent deterioration of respiratory function. Despite the importance of this circuit, reports about the utility in tuberculosis sometimes are controversial or not conclusive. With the aim of knowing and integrate the information published, in this review we search and analyze different studies that look forward to defining the eicosanoids’ role on M. tuberculosis infection. For this, we review the role of eicosanoids post-infection in vivo or in vitro, and the modification of their metabolic route before or after infection. We also propose an algorithm to optimize the future investigations of eicosanoids and their utility as therapeutic target during TB.

Keywords : tuberculosis; eicosanoids; host-directed therapies.