Abstract

LOPEZ-DE LA CRUZ, Paola L; RUIZ-PEREZ, Samuel  and  LANIADO-LABORIN, Rafael. Use of bedaquiline during pregnancy in a patient with MDR-TB. First case reported in Mexico. Neumol. cir. torax [online]. 2022, vol.81, n.2, pp.138-140.  Epub Aug 28, 2023. ISSN 0028-3746.  https://doi.org/10.35366/108501.

Treatment of rifampin-resistant and multidrug-resistant tuberculosis in pregnant women is more complicated since little is known about the safety of second-line antituberculosis drugs during pregnancy and lactation. Drug-resistant tuberculosis, not having many options in the past, has been treated with regimens that include drugs with teratogenic potentials, such as thioamides and second-line injectables. Currently, there are new oral drugs, including bedaquiline, for the treatment of drug-resistant disease; however, the safety of bedaquiline during pregnancy and lactation has not been satisfactorily demonstrated so far. We report the first case in Mexico treated with a regimen that includes bedaquiline for multidrug-resistant tuberculosis during pregnancy, with favorable results, and without maternal-fetal complications.

Keywords : tuberculosis; rifampin-resistant; multidrug-resistant; pregnancy; bedaquiline.

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