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Revista de investigación clínica
On-line version ISSN 2564-8896Print version ISSN 0034-8376
Abstract
OCHOA-HEIN, Eric et al. Significant Rise in SARS-CoV-2 Reinfection Rate in Vaccinated Hospital Workers during the Omicron Wave: A Prospective Cohort Study. Rev. invest. clín. [online]. 2022, vol.74, n.4, pp.175-180. Epub Sep 30, 2022. ISSN 2564-8896. https://doi.org/10.24875/ric.22000159.
Background:
Relatively low SARS-CoV-2 reinfection rates have been reported in vaccinated individuals, but updates considering the Omicron variant are lacking.
Objective:
The objective of the study was to provide a current estimate of the SARS-CoV-2 reinfection rate in a highly immunized population.
Methods:
A prospective cohort of Mexican hospital workers was followed (March 2020-February 2022). Reinfection was defined as the occurrence of two or more episodes of COVID-19 separated by a period of ≥ 90 days without symptoms. The reinfection rate was calculated as the number of reinfection episodes per 100,000 persons per day.
Results:
A total of 3732 medical consultations were provided to 2700 workers, of whom 1388 (51.4%) were confirmed COVID-19 cases. A total of 73 reinfection cases were identified, of whom 71 (97.3%) had completed their primary vaccination series and 22 (30.1%) had had a booster dose before the second episode. The overall reinfection rate was 23.1 per 100,000 persons per day (as compared to a rate of 1.9 per 100,000 persons per day before the Omicron wave).
Conclusions:
The SARS-CoV-2 reinfection rate rose significantly during the Omicron wave despite a high primary vaccination coverage rate. Almost one-third of reinfected workers had a vaccine booster ≥ 14 days before the last COVID-19 episode.
Keywords : COVID-19; SARS-CoV-2; Reinfection; Health personnel; Omicron.