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Salud Pública de México
Print version ISSN 0036-3634
Abstract
VILLA-ROSAS, Cecilia; LANIADO-LABORIN, Rafael and OCEGUERA-PALAO, Lorena. Primary drug resistance in a region with high burden of tuberculosis: A critical problem. Salud pública Méx [online]. 2015, vol.57, n.2, pp.177-179. ISSN 0036-3634.
Objective. To determine rates of drug resistance in new cases of pulmonary tuberculosis in a region with a high burden of the disease. Materials and methods. New case suspects were referred for drug susceptibility testing. Results. 28.9% of new cases were resistant to at least one first line drug; 3.9% had a multidrug-resistant strain, 15.6% a monoresistant strain and 9.4% a polyresistant strain. Conclusion. Our rate of drug resistant tuberculosis in new cases is very high; this has important clinical implications, since even monoresistance can have a negative impact on the outcome of new cases treated empirically with a six month regimen.
Keywords : treatment outcome; resistance amplification; isoniazid; rifampin.