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Salud Pública de México
Print version ISSN 0036-3634
Abstract
PERALTA-ARRIETA, Irlanda; ARMAS-LOPEZ, Leonel; ZUNIGA, Joaquín and AVILA-MORENO, Federico. Epigenetics in non-small cell lung carcinomas. Salud pública Méx [online]. 2019, vol.61, n.3, pp.318-328. Epub Mar 03, 2020. ISSN 0036-3634. https://doi.org/10.21149/10089.
Objective:
To perform a systematic review of the main epigenetic aberrations involved in non-small cell lung carcinomas’ (NSCLC) diagnosis, progression, and therapeutics.
Materials and methods:
We performed a systematic review of the scientific literature on lung cancer epigenetics, focusing on NSCLC.
Results:
Several advances in the molecular study of classical epigenetic mechanisms and massive studies of lung cancer epigenome have contributed relevant new evidence revealing that various molecular complexes are functionally influencing genetic-epigenetic and transcriptional mechanisms that promote lung tumorigenesis (initiation, promotion, and progression), and are also involved in NSCLC therapy-resistance mechanisms.
Conclusion:
Several epigenetic complexes and mechanisms must be analyzed and considered for the design of new and efficient therapies, which could be fundamental to develop an integrated knowledge to achieve a comprehensive lung cancer personalized medicine.
Keywords : non-small cell lung cancer; epigenetics; biomarkers; DNA.