Objectives:

Our aim was to examine prospectively predictors of subclinical renal alterations among adults without chronic kidney disease.

Materials and methods:

We analyzed data from a cohort of Mexican adults (n=757). Kidney function (2010) was assessed with the estimated glomerular filtration rate (eGFR-Cr), serum creatinine and uric acid. Predictors of each kidney function marker (2004) were identified with linear and logistic regression models.

Results:

33% had an eGFR-Cr <90 ml/min/1.73 m2. eGFR-Cr was lower among men, those >40 years old and users of antihypertensive medication; and higher among those with a high protein intake. Serum creatinine predictors were similar to those observed for eGFR-Cr. Uric acid decreased in men, among those with obesity, hypertension and high cholesterol.

Conclusion:

Conventional kidney function biomarkers are useful to identify subclinical alterations. Some predictors of kidney function are potentially modifiable, therefore susceptible for intervention among high-risk groups.