Abstract

MORALES-GARCIA, Victor Daniel; GARZA-MERCADO, Román; TAMEZ-MONTES, Dagoberto  and  MARTINEZ-PONCE DE LEON, Ángel. Efficacy of prophylactic intraventricular vancomycin in patients with ventriculostomy. Arch. Neurocien. (Mex., D.F.) [online]. 2005, vol.10, n.3, pp.128-132. ISSN 1028-5938.

To determine the efficacy of administration prophylactic Intraventricular vancomycin in patients with ventriculostomy. Material and method: from December 2003 to November 2004. The study was performed randomized, blind and prospective with case control. Patients with sterile hydrocephaly were administered 10 mg of vancomicyn per application into ventriculstomy for no more than 10 days. Prophylactic efficacy and security were evaluated. Results: 10 patients in case group and 17 in control group were included. Intraventricular hemorrhage was the most common cause of hydrocephalus. No infection was reported in the group case but 47% were infected in the control group. Staphylococcus was the most common cause of infection. No secondary effect was documented for application of intraventricular vancomycin. Conclusion: the prophylactic treatment of intraventricular vancomycin on patients with ventriculostomy was effective and secure.

Keywords : vancomycin; ventriculostomy; prophylactic vancomycin.