Abstract

NARES-TORICES, Miguel Ángel et al. Active systemic lupus erythematosus during pregnancy. Clinical course and prognosis in an Intensive Care Unit. Perinatol. Reprod. Hum. [online]. 2012, vol.26, n.2, pp.96-105. ISSN 2524-1710.

Introduction: Systemic lupus erythematosus (SLE) complicates one of every 1,000 pregnancies in Latin American population, 10 to 25% of, patients with systemic rheumatic disease, require hospitalization while attend to emergency room, and 30% of these require intensive care treatment. The death incidence in SLE patients in intensive care units can be up to 79%. Objective: Describe the clinical course and prognosis of pregnant women who were diagnosed with active systemic lupus erythematosus (ASLE), admitted to an intensive care unit. Material and methods: Between January 2005 and December 2009 at the intensive care unit of the Instituto Nacional de Perinatología (INPer), 23 pregnant patients diagnosed and treated with ASLE, were studied to determine, the clinical course and prognosis. Results: High frequencies in intrauterine growth restriction (39%), preterm delivery (80%), fetal death (13%), severe preeclampsia (30.4%) and maternal death (17%) were seen. Also found significant differences in proteinuria, uric acid, IUGR and fetal death in those patients who had preterm birth and those who had not. Conclusions: Active systemic lupus erythematosus associated with pregnancy, has high frequency of adverse perinatal outcomes, like premature delivery and severe preeclampsia. So it has to be considered, that this type of patients must be controlled and treated in the appropriate facility by an interdisciplinary professional team, with the aim of consider diminishing those complications.

Keywords : Active systemic lupus erythematosus; pregnancy complications.

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