Abstract

MANTEROLA-ALVAREZ, David; HERNANDEZ-PACHECO, José Antonio  and  ESTRADA-ALTAMIRANO, Ariel. Chronic renal disease during pregnancy: clinical course and perinatal outcomes at the Instituto Nacional de Perinatología Isidro Espinosa de los Reyes. Perinatol. Reprod. Hum. [online]. 2012, vol.26, n.4, pp.147-153. ISSN 2524-1710.

Objective: To describe the clinical and demographic characteristics of patients admitted to the Instituto Nacional de Perinatología with chronic kidney disease and pregnancy, as well as to describe the clinical course of pregnancy, kidney disease and perinatal outcomes achieved. Study design: Simple cohort study in which records were reviewed of all patients diagnosed with chronic kidney disease and pregnancy admitted to the Instituto Nacional de Perinatología, during the period of January 2004 to December 2007; statistical analysis we obtained mean and standard deviation for numeric variables and proportions for nominal and categorical variables. Results: Evaluate a total of 47 patients in which the average age was 25.8 ± 5.6 years, mean gestational age of initiation of prenatal care was 17.6 ± 6.2 weeks. The incidence of chronic kidney disease and pregnancy of our study was 0.33%. The most common etiology of chronic kidney disease was sistemic chronic hypertension in 38.3% of cases. The stage of chronic kidney disease at the time of admission was: mild in 31.9% of patients, moderate in 29.8% and severe in 38.3%. The mean serum creatinine at admission was 2.7 (± 1.90) mg / dL and after delivery 4.4 (± 2.80) mg / dL. The creatinine clearance average at admission was 33.8 (± 20.58) mL / min and after the resolution of pregnancy was 24.1 (± 15.69) mL / min. Anemia was present in 57.4% of these patients. 46.8% of pregnant women showed deterioration in renal function and 27.6% developed preeclampsia. Dialysis was required in nine cases (19.1%). The most common way to conclude pregnancy was by cesarean section in 76.6% of cases, and the maternal preeclampsia, was the indication more frequent in (27.7%) and then renal function impairment (14.9%). Fetal indications were 23.4% and the most common was intrauterine growth restriction (10.6%) then fetal unreliable stage (6.4%). The most common destination after birth was the neonatal therapy in 59.6% of cases, and the overall survival of 83%. Conclusion: The most common perinatal complications were preeclampsia, impaired renal function, anemia, prematurity and intrauterine growth restriction.

Keywords : Chronic kidney disease; pregnancy; perinatal outcomes.