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Perinatología y reproducción humana
On-line version ISSN 2524-1710Print version ISSN 0187-5337
Abstract
OSTIA-GARZA, Patricia J.; JIMENEZ-DIAZ, Luis D. and PLAZA-BENHUMEA, Lautaro. MURCS association: case report in a female newborn. Perinatol. Reprod. Hum. [online]. 2022, vol.36, n.2, pp.56-60. Epub Dec 01, 2022. ISSN 2524-1710. https://doi.org/10.24875/per.21000001.
Background:
MURCS refers to the preferential association of müllerian duct and kidney aplasia and cervicothoracic vertebrae anomalies. Of unknown etiology, it is usually sporadic.
Objectives:
To describe newborn female case of MURCS with additional anomalies and to discuss possible pathogenetic mechanisms and etiology.
Discussion:
The spectrum of MURCS is unknown. Vertebral, urogenital and anal defects can be explained by abnormal interactions between the embryonic precursors that show a close spatial relationship during early development: paraxial (spine), intermediate (ureters, kidney), and lateral mesoderm (coelomic epithelium: adrenal glands, ovaries, uterus; uro-rectal septum: anus). We emphasize the importance of interdisciplinary care, including a clinical geneticist in the care of patients with these characteristics.
Keywords : MURCS; Recurrence; Müllerian duct; Congenital abnormalities; Scoliosis.
