Abstract

CASTILLEJOS LOPEZ, Manuel de Jesús; PEREZ PADILLA, Rogelio; QUINONES FALCONI, Francisco  and  GARCIA SANCHO FIGUEROA, Ma. Cecilia. Implication of single nucleotide polymorphisms in Mycobacterium tuberculosis and humans in the clinical management of tuberculosis. Rev. Inst. Nal. Enf. Resp. Mex. [online]. 2006, vol.19, n.1, pp.38-46. ISSN 0187-7585.

We review studies of Mycobacterium tuberculosis genetic polymorphisms associated to resistance and transmission; also, the genetic polymorphisms associated to severity and clinical presentation of human tuberculosis (TB) and hepatic toxicity associated to antituberculosis treatment. We discuss its usefulness in studies of patients with multidrug resistant TB. The new methods of genomic medicine suggest new criteria for immediate application in TB management, the evaluation of treatment efficacy and the prevention of patient complications. It is important to appraise cost-benefit of this tool to improve TB medical care centers from developing countries with high rates of TB.

Keywords : Efficacy; genotyping; multidrug resistance; Mycobacterium tuberculosis; polymorphisms; tuberculosis.