Abstract

CONTRERAS-ZARATE, Magdalena et al. Homocysteine (HCY), uric acid and their relationship with HDL in patients with coronary artery disease. Rev. Mex. Cardiol [online]. 2012, vol.23, n.2, pp.58-63. ISSN 0188-2198.

Introduction: Coronary heart disease (CHD) is the main cause of death in Mexico. Homocisteine (HCY), uric acid (UA) and cholesterol (c-HDL) are known independent factors for cardiovascular disease. Objective: To investigate the relationship between HCY, UA and c-HDL in patients with Coronary Heart Disease (CHD). Material and methods: Comparative cross-sectional study in 75 patients with CHD, without diuretics, allopurinol, folic acid, B complex and without kidney or thyroid disease. To each patient was collected a fasting blood sample for quantification of HCY, UA, glucose and lipid profile. The statistical analysis was realized in SPSS V18. Results: Mean age was 60.96 ± 16.22 years. 58.45% had type 2 diabetes and/or hypertension. Patients were divides in 2 groups: UA ≥ 7 mg/dL y UA < 7 mg/dL. We found differences in HCY, c-HDL, systolic and diastolic blood pressure (p < 0.005). The UA correlated with c-HDL(r = -0.307, p = 0.010) and HCY with c-HDL (r = -0.283, p = 0.019). In the linear regression analysis was found to HCY as predictor of UA (standardized coefficient β:0.294, t:2.458, p = 0.017) and c-HDL (standardized coefficient β:0.269, t:2.232, p = 0.029). Conclusions: There is relationship between HCY, UA with c-HDL and c-HDL. HCY is a predictor of hyperuricemia, low c-HDL levels in patients with CHD. It is recommended to include the determination of HCY as routine in patients with a family history of CHD.

Keywords : Homocysteine; hyperuricemia; coronary heart disease.