Abstract

MARTINEZ DOMINGUEZ, Anabella; CONTRERAS, Irazú  and  ESTRADA, José Antonio. Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice. Acta univ [online]. 2017, vol.27, n.6, pp.78-83. ISSN 2007-9621.  https://doi.org/10.15174/au.2017.1346.

Oxidative stress (OS) is considered a risk factor for neurodegenerative disorders. Iron concentrations have been related to OS; however, the effect of iron deficiency (ID) on the induction of OS in the central nervous system (CNS) is unknown. A murine model of chronic diet-induced ID using 2 month-old male BALB/c mice (6 specimen), was used to determine its role in OS induction. Lipid peroxidation was determined by measuring thiobarbituric acid-reactive species (TBARS) in the CNS, using the spleen for comparison. A decrease of peroxidation products in the CNS of the ID group (ID CNS), compared to controls fed on a regular diet, was found. The spleen showed a significant increase of lipid peroxidation in the ID group. Our results suggest that chronic ID may have differential effects on OS in the CNS and peripheral tissues. A decreased amount of reactive oxygen species in the basal state may be related to alterations on normal CNS metabolism and functions under chronic ID.

Keywords : Oxidative stress; lipid peroxidation; iron deficiency; central nervous system; spleen.

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