Abstract

PEREZ BONILLA, María Eugenia; REYES MONREAL, Marleni; PEREZ ESCALERA, Miguel Felipe  and  REYES LAZALDE, Arturo. Set of Simulators of the Electrophysiology of the A-Type Potassium Current (I_A) in Neurons. Rev. mex. ing. bioméd [online]. 2020, vol.41, n.3, e1059.  Epub Jan 27, 2021. ISSN 2395-9126.  https://doi.org/10.17488/rmib.41.3.2.

The A-type potassium current (IA) participates in important brain functions, including neuronal excitability, synaptic integration, and regulation of action potential patterns and firing frequency. Based on the characterization of its electrophysiological properties by current and voltage clamp techniques, mathematical models have been developed that reproduce IA function. For such models, it is necessary to numerically solve equations and utilize hardware with special speed and performance characteristics. Since specific software for studying IA is not found on the Internet, the aim of this work was to develop a set of simulators grouped into three computer programs: (1) IA Current, (2) IA Constant-V Curves and (3) IA AP Train. These simulators provide a virtual reproduction of experiments on neurons with the possibility of setting the current and voltage, which allows for the study of the electrophysiological and biophysical characteristics of IA and its effect on the train of action potentials. The mathematical models employed were derived from the work of Connor et al., giving rise to Hodgkin-Huxley type models. The programs were developed in Visual Basic® and the differential equation systems were simultaneously solved numerically. The resulting system represents a breakthrough in the ability to replicate IA activity in neurons.

Keywords : A-type potassium current; simulators; virtual experiments.

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