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Ginecología y obstetricia de México
Print version ISSN 0300-9041
Abstract
OVIEDO-CRUZ, H; REYES-MENDOZA, MA and MESTIZO-REYES, V. Medians correction of free beta subunit of human chorionic gonadotropin and pregnancy-associated plasma protein-A during the first trimester for a Mexican population sample. Ginecol. obstet. Méx. [online]. 2017, vol.85, n.12, pp.787-798. ISSN 0300-9041. https://doi.org/10.24245/gom.v85i12.994.
Objective:
To determine whether first trimester serum markers distribution on a Mexican population sample differ from The Fetal Medicine Foundation (FMF) risks model, and to calculate the necessary correction factors for accurate test performance.
Materials and Method:
Transverse descriptive study, Free-beta-hCG and PAPP-A were measured on unselected first trimester maternal sera using FMF approved electrochemiluminescence assay, the adjusted MoM were obtained from FMF algorithm (astraia); they were log10 transformed to describe each marker distribution and to test their statistical difference with the 0.000 ideal mean by one sample t-test. MoM distributions for pregnancy characteristics and reagent lot are additionally described.
Results:
On 1008 sera, the overall adjusted log10MoM was -0.121 ± 0.2706 SD for Free-beta-hCG and -0.049 ± 0.2372 SD for PAPP-A; these distributions differed significantly from tåzhe expected by FMF risks model.
Conclusions:
Free-beta-hCG and PAPP-A distributions on this Mexican population sample differ from expected for population similar to Hispanic European, median correction factors of 0.756 MoM and of 0.893 MoM, respectively, are recommended for the algorithm.
Keywords : Aneuploidies; Free-beta-hCG; Combined screening; Trisomy 21 screening; First trimester screening preeclampsia.
