Objective:

To compare plasma coloidosmotic pressure of patients with severe preeclampsia at sea level with Mexico City.

Materials and methods:

Cross-sectional study that included 372 pregnant patients with severe preeclampsia: 172 residents of the area of Ciudad Obregon, Sonora, Mexico, located at 40 meters above sea level, and 200 patients living in Mexico City, at an altitude of 2,250 meters. Clinical laboratory results were consulted to calculate plasma coloidosmotic pressure and perform comparison. For statistical analysis, descriptive and inferential statistics (Student t test, Pearson correlation coefficient) were used. Value of p < 0.05 was considered significant. Statistical program Spreeclampsia severaS version 20 was used.

Results:

The mean plasma coloidosmotic pressure of patients of Ciudad Obregon was 18.10 ± 2.18 mmHg (range 11.88 to 21.80), and in patients from Mexico City was 18.93 ± 2.72 mmHg (range 10.31 to 23.94), with significant difference (p = 0.0016). Mean albumin was 2.49 ± 0.35 vs 2.81 ± 0.44 g/dL (p = 0.0208) and globulin 2.99 ± 0.57 vs 2.30 ± 0.48 g/dL (p = 0.0118). Correlation plasma coloidosmotic pressure vs albumin was Ciudad Obregon 0.927 and Mexico City 0.969.

Conclusion:

Plasma coloidosmotic pressure of pregnant patients with severe preeclampsia in a geographic area at sea level with Mexico City was different. It would be convenient to perform regional measurements of plasma coloidosmotic pressure to establish its value according to the characteristics of both patient and geographic area.

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