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Ginecología y obstetricia de México
Print version ISSN 0300-9041
Abstract
SAUCEDO, Renata et al. Relationship between uric acid and body composition, metabolic profile, leptin and adiponectin in postmenopausal women. Ginecol. obstet. Méx. [online]. 2019, vol.87, n.5, pp.311-318. Epub June 30, 2021. ISSN 0300-9041. https://doi.org/10.24245/gom.v87i5.2943.
OBJECTIVE:
To determine the relation between uric acid and metabolic and anthropometric parameters and adipokines leptin and adiponectin in post-menopausal women.
MATERIALS AND METHODS:
A descriptive cross-sectional study was performed in post-menopausal women. Anthropometric measurements were taken by electric bioimpedance, and fasting venous blood samples were taken to determine glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides by enzyme techniques, and levels of adiponectin, leptin and insulin were measured by radioimmunoassay. Insulin resistance was calculated using HOMA-IR. The variables were described with mean and standard deviation. Statistical analysis was performed by Pearson correlation test to evaluate the relation between uric acid and the study variables, and a multiple regression was performed to determine the parameters with greatest influence on uric acid.
RESULTS:
The study included 90 post-menopausal women aged 55 to 84 years. The average age of the participants was 63.7 years, and the average concentration of uric acid was 4.9 mg/dL. In bivariate analysis, anthropometric parameters, LDL-cholesterol, triglycerides and leptin showed positive association with uric acid, and HDL-cholesterol and adiponectin had a negative one. In multiple regression analysis, body fat associated with uric acid independent of body weight (beta=0.592, p=0.037).
CONCLUSIONS:
Uric acid relates with an adverse cardio-metabolic profile in post-menopausal women.
Keywords : Uric acid; Postmenopause; Body weight; Adipose tissue; Cholesterol; Triglycerides; Insulin resistance.