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Ginecología y obstetricia de México
Print version ISSN 0300-9041
Abstract
POLANCO-SOSA, Ana Lucía; PENA-MONTEMAYOR, Ana Karen and MIRELES-GARCIA, Angélica Marlene. Mixed ovarian germ cell tumor, an unusual combination. Ginecol. obstet. Méx. [online]. 2020, vol.88, n.2, pp.123-126. Epub Aug 30, 2021. ISSN 0300-9041. https://doi.org/10.24245/gom.v88i2.3577.
BACKGROUND:
Ovarian germ cell tumors are rare, clinically and biologically heterogeneous tumors, formed by several types of histopathologically different tumors that derive from primitive cells and that are nested ectopically, proliferate and undergo malignant transformation.
CLINICAL CASE:
A 10-year-old patient who came to consult for weight loss and abdominal pain as well as an increase in abdominal perimeter of rapid growth. A fixed abdominal tumor of 20 x 20 cm is scanned and found, as well as palpable left cervical lymph node. Tumor markers showing alphafetoprotein were taken. 1104 ng/mL, B-HCG 865.6 mUi/mL. The CT scan showed a lesion that occupies abdomen and pelvis with a heterogeneous density of 14 x 12 x 10 cm. It was decided to intervene surgically and complement with chemotherapy; The pathology report reported being a mixed germ tumor with 5 very aggressive histological types that ended with the patient´s life 9 months later.
CONCLUSION:
Malignant germ cell tumors are extremely malignant and rapidly growing, with a peak incidence in girls, adolescents and young women. Symptoms are related to rapid growth characterized by pelvic-abdominal pain related to capsular distention, hemorrhage or necrosis. Surgical staging is the first step in the treatment of ovarian germ cell cancer. The survival rate is greater than 95% in early stage (l-ll), 80% in stage lll and 60% in stage lV, so the diagnosis and timely treatment is the most important.
Keywords : Ovarian germ cell tumor; Abdominal tumor; Ovarian germ cell cancer; Survival rate; Biomarkers, Tumor; Weight Loss; Ovarian neoplasms.