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Ginecología y obstetricia de México
Print version ISSN 0300-9041
Abstract
BARROSO-VILLA, Gerardo et al. Euploid blastocyst rate in follicular vs luteal phase (DuoStim) in women with poor ovarian response: Preliminary study in Mexico. Ginecol. obstet. Méx. [online]. 2020, vol.88, n.5, pp.306-311. Epub Sep 20, 2021. ISSN 0300-9041. https://doi.org/10.24245/gom.v88i5.3935.
OBJECTIVE:
Euploid blastocyst rate comparison between ovarian stimulation in follicular vs luteal phase performed in the same menstrual cycle in patients with poor ovarian response.
MATERIALS AND METHODS:
Clinical, prospective and comparative study conducted at Centro de Reproducción Arcos S.C., “Nascere”, during january-july, 2019. Patients with PGT-A indication and poor ovarian response according to Bologna criteria were included. Under a short GnRH-antagonist protocol, stimulations, both in follicular and luteal phase were performed using rFSH/rLH (2:1) from day 3 of the cycle and 5 days after the first oocyte retrieval. In addition, ovulation trigger with an GnRH agonist was used, finally, on day 5-6 of embryo development, trophoctoctoderm biopsy was performed.
RESULTS:
In this study, 20 patients were included; when comparing follicular phase vs luteal phase, we found that fertilization rate was 79% (95%CI 29-46) vs 55% (95%CI 34-53), blastocysts rate was 42% (95%CI 19-44) vs 45% (95%CI 24-55) and euploid embryo rate was 100% (95%CI 44-53) vs 70% (95%CI 38-46). Only the oocyte recovery rate in metaphase II showed significant differences between both phases 40% (IC 95% 18-37) vs 59% (IC 95% 31-59), p=0.0333.
CONCLUSION:
Biphasic ovarian stimulation (follicular/ luteal) in the same menstrual cycle (DuoStim) resulted in a higher metaphase II ooctye recovery rate during the luteal phase in comparison with the follicular phase. However, the rates of blastocysts and euploid blastocysts were similar between both phases.
Keywords : Blastocyst; Ovarian stimulation; Luteal phase; Menstrual cycle; Follicular phase; Oocyte retrieval; Metaphase; Ovulation induction.