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Ginecología y obstetricia de México
Print version ISSN 0300-9041
Abstract
SANCHEZ-GONZALEZ, Cristina Magaly et al. A combined in-vitro fertilization strategy: minimal stimulation IVF, PGT-A and SET. Results from 3 years’ experience at two IVF centers in Mexico. Ginecol. obstet. Méx. [online]. 2020, vol.88, n.8, pp.508-516. Epub Sep 24, 2021. ISSN 0300-9041. https://doi.org/10.24245/gom.v88i8.3490.
OBJECTIVE:
To evaluate results of a combined approach in IVF, using minimal stimulation, preimplantation genetic testing for aneuploidy, and single blastocyst transfer.
MATERIALS AND METHODS:
Retrospective cohort study over a three years’ period in two fertility centers in Mexico. A total of 125 patients were included, between 25 and 45 years old, with minimal stimulation IVF, preimplantation genetic testing for aneuploidy (PGT-A) and single euploid embryo transfer. PGT was performed using microarrays and next generation sequencing (NGS).
RESULTS:
A total of 175 cycles (mean age: 39 years old) were analyzed in 125 patients. On average, five eggs were collected per cycle; fertilization rate was 86.57%; blastocyst rate was 50.7% per fertilized egg. Only 33% of embryos were euploid. Pregnancy rate per transferred embryo was 71%. Live birth rate was 60.8% (42 births).
CONCLUSIONS:
A combination of minimal stimulation, PGT-A and single blastocyst embryo transfer can yield a high live birth rate.
Keywords : IVF; Genetic testing; Aneuploidy; Blastocyst transfer; minimal stimulation; Birth rate.
