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Ginecología y obstetricia de México
Print version ISSN 0300-9041
Abstract
GARZA-GARZA, Mario Alberto et al. Correlation of vitamin D values with those of anti-Müllerian hormone in infertile women. Ginecol. obstet. Méx. [online]. 2020, vol.88, n.12, pp.833-838. Epub Oct 18, 2021. ISSN 0300-9041. https://doi.org/10.24245/gom.v88i12.4498.
OBJECTIVE:
To evaluate the association between serum concentrations of 25-hydroxyvitamin D and antimullerian hormone in Mexican patients with infertility.
MATERIALS AND METHODS:
Retrospective, cross-sectional study of relational analysis of patients who came to consult at the IECH Fertility Center between the months of May 2019 and May 2020. The Kolmogorov-Smirnov normality test was used, with means and standard deviations (SD) for normal values; medians and interquantity ranges (IQR) for non-parametric values. To show differences between the groups the paired t-test and Mann-Whitney test were applied depending, respectively, on the normality of the data and the Spearman correlation coefficient to calculate the dependence between non-parametric variables. GraphPad Prism (v 8) was used, the value of p < 0.05 was considered with statistical significance.
RESULTS:
A total of 106 files of patients diagnosed with infertility with a mean age of 35 4.97 and a median of 19.90 ng/mL (IQR 57.06) of 25-hydroxyvitamin D were analyzed. Vitamin D deficiency (less than 20 ng/mL) was not associated with antimullerian hormone values (p = 0.0525); a difference was found between vitamin D concentrations for patients younger and older than 35 years (p = 0.0423) and a correlation between vitamin D and antimullerian hormone (Spearman’s rho: -0.210, 95%CI -0.41 to -0.005, p = 0.0495).
CONCLUSIONS:
50% of the infertile patients had vitamin D deficiency. Although the mechanism is not properly elucidated, there is a dependence on the values of 25-hydroxyvitamin D and the antimullerian hormone.
Keywords : 25-hydroxyvitamin D; Anti-Müllerian hormone; Reference values; Vitamin D deficiency; Infertility.