BACKGROUND:

Sarcomas are rare primary malignant neoplasms of soft tissue or bone. Since 1963, only 19 and 14 cases of pregnancy-associated Ewing sarcoma and rhabdomyosarcoma, respectively, have been reported.

OBJECTIVE:

To report the perinatal outcomes of two patients seen at the National Institute of Perinatology with a diagnosis of Ewing sarcoma and alveolar rhabdomyosarcoma.

CASE 1:

22-year-old patient, 23 weeks pregnant, with a 20 cm tumor in the left gluteal region, with pain and difficulty in ambulation. Chest X-ray showed multiple pulmonary nodules. Magnetic resonance imaging showed a tumor in the gluteal region with extensive involvement that was diagnosed as stage IV metastatic Ewing's sarcoma. Treatment was symptomatic, with termination of pregnancy at 28 weeks.

CASE 2:

22-year-old patient, 12 weeks pregnant and diagnosed with metastatic medullary syndrome. Decompression of T9-11 was performed. Upon evidencing the absence of fetal heart rate, deferred abortion was decided.

CONCLUSIONS:

The definitive diagnosis of these sarcomas is established based on biopsy. The hormonal and immunologic changes of pregnancy affect their evolution and have important repercussions on adverse maternal and fetal outcomes. The care of these patients should be multidisciplinary, and advice should be given not to become pregnant until the tumor disappears.