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Ginecología y obstetricia de México
Print version ISSN 0300-9041
Abstract
MARTINEZ-LAZCANO, Félix et al. Association between hyperparathyroidism secondary to vitamin D deficiency in pregnancy and the frequency of preeclampsia. Ginecol. obstet. Méx. [online]. 2022, vol.90, n.8, pp.647-654. Epub Sep 26, 2022. ISSN 0300-9041. https://doi.org/10.24245/gom.v90i8.7642.
OBJECTIVE:
To establish whether there is an association between hyperparathyroidism secondary to vitamin D deficiency in pregnancy and the frequency of preeclampsia.
MATERIALSAND METHODS:
Case-control, prospective, longitudinal study performed in patients with and without preeclampsia who between January 1 and June 30, 2021 attended the Hospital Universitario of the Universidad Autónoma de Nuevo Leon for delivery care. Inclusion criteria: pregnant patients with a diagnosis of preeclampsia in the last trimester of gestation with blood pressure equal to or greater than 140-90 mmHg and proteinuria equal to or greater than 30 mg/dL. For the control group: healthy pregnant women without a diagnosis of preeclampsia in the last trimester of gestation. Exclusion criteria: smoking, alcoholism and drug addiction and those who did not agree to enter the study or had a diagnosis of chronic medical diseases.
RESULTS:
We studied 90 patients divided into two groups: with preeclampsia (n = 45) and without preeclampsia (control, n = 45). A relationship was found between vitamin D deficiency, hypocalcemia, and preeclampsia; a relationship was not found between parathormone and preeclampsia in the international parathormone ranges. Preeclampsia was found more frequently in patients aged 12 to 15 years.
CONCLUSIONS:
Hyperparathyroidism secondary to vitamin D deficiency in pregnancy was not observed in patients with preeclampsia; those who had it had parathormone concentrations in normal limits. A relationship was found between vitamin D deficiency, hypocalcemia, and preeclampsia.
Keywords : Hyperparathyroidism; Vitamin D deficiency; Parathyroid hormone; Pregnancy; Pre-Eclampsia; Blood pressure; Pregnancy Trimester, Third.