Abstract

MISHRA, Sunil Kumar; SINGH, P. N.  and  DUBEY, S. D.. Evaluation of antioxidant activities in ethanolic extract of Capparis Zeylanica Linn. Root.. Rev. latinoam. quím [online]. 2013, vol.41, n.1, pp.7-20. ISSN 0370-5943.

The in vitro antioxidant activity of the Capparis Zeylanica extract showed that has a scavenging ability of hydroxyl peroxide radicals (421.74 ± 25.61 mg/ml) and DPPH radical scavenging activity (around 95%). In vivo study in rats with Capparis Zeylanica extract showed significant antioxidant activity in the DPPH test as compared to the control. Capparis Zeylanica extract at doses of 100 and 200 mg/ kg significantly increased rats TAP as compared to control where as the decreased in TBARS was significant in 200 and 400 mg/kg compared to the control. Administration of Capparis Zeylanica extracts at a dose of 400 mg/kg per day did not significantly alter serum TAP but little alteration was observed in TBARS test. Antioxidant activities of the extract at doses of 100 and 200 mg/kg were in all experiments comparable to that of α-tocopherol (10 mg/kg). A good result for DPPH and TBARS was found at a dose of 400 mg/kg compared to the α-Tochopherol. Dose dependent effect was found in DPPH scavenging activity. The constituents like total phenolic compounds (43.625 ± 1.45 mg/g of dry extract), total tannins (24.75 ± 1.23 mg/g of dry extract), total flavonols (1.653 ± 1.41mg rutin equivalents/g dry extract), total flavonoids (0.876 ± 0.26 mg/g Rutin/g of dry extract), Saponins (1.22 ± 1.35 mg/g of dry extract) and fatty acids (0.0867 ± 0.01 mg/g of dry extract) indicate that the Capparis Zeylanica root extract may contribute to the antioxidant activity.

Keywords : Capparis Zeylanica; DPPH; TAP; FRP; TBARS; phenolics.