Abstract

BADARY, Osama A et al. Study of the effect of Allium porrum on hypertension induced in rats. Rev. latinoam. quím [online]. 2013, vol.41, n.3, pp.149-160. ISSN 0370-5943.

The present study was design to investigate the effect of alcoholic extract of Allium porrum (250 and 500mg/kg) on hypertension induced experimentally in male rats by oral administration of L-NG-Nitroarginine methyl Ester (L-NAME) (50mg/kg/day) for four successive weeks. Alcoholic extract of Allium porrum (250 and 500mg/kg) was administered by oral route daily for 8 weeks before hypertension induction and 4 week simultaneously with L-NAME. Systolic blood pressure (SBP) was measured every week by tailcuff method; blood samples were collected at the end of the experiments for determination of serum cholesterol, nitric oxide, malondialdehyde and total antioxidant capacity. Oral administration of alcoholic extract of Allium porrum (250 and 500m/kg) resulted in a significant reduction of the elevated SBP induced by L-NAME (50mg/ kg) compared with hypertensive control group. It was also observed that alcoholic extract of Allium porrum showed a significant antioxidant activity and hypochlolesterolemic effect, in addition to increase significantly serum nitric oxide. It is concluded that alcoholic extract of Allium porrum have promising effect in experimentally induced hypertension in rats, which may be attributed to its antioxidant capacity.

Keywords : Allium porrum; hypertension; antioxidant; rats.

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