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Revista de la Sociedad Química de México
Print version ISSN 0583-7693
Abstract
GILI, Pedro and MEDEROS, Alfredo. On the Toxicity of the Aromatic Diamines and their Tetramethylcarboxylic Acid Derivatives. Rev. Soc. Quím. Méx [online]. 2000, vol.44, n.2, pp.104-107. ISSN 0583-7693.
The use of the theoretical PALLAS 3.0 program, to study the toxic behaviour of tetramethylcarboxylic acids, potential pharmaceuticals derived from o-phenylenediamines, indicates that o-phenylenediamines are highly toxic (level 1), while the tetramethycarboxylic acid derivatives (o-PhDTA and 3,4-TDTA) are slightly toxic, similar to EDTA (level 3). Therefore these ligands o-PhDTA and 3,4-TDTA, similar to EDTA, can be used as sequestering agents of toxic metals and overload of essential metals in biological systems.
Keywords : Theoretical program; toxicity; aromatic diamines; tetra-methylcarboxylic acid derivatives.