Abstract

AGUILAR, María Isabel; DELGADO, Guillermo  and  VILLARREAL, María Luisa. New Bioactive Derivatives of Xanthorrhizol. Rev. Soc. Quím. Méx [online]. 2001, vol.45, n.2, pp.56-59. ISSN 0583-7693.

The chemical preparation and the antifungic and cytotoxic evaluations of several new derivatives of xanthorrhizol, a bioactive natural product isolated from certain plants used in traditional medicine, are described. Acylation of the phenol, bromination of the benzene ring, as well as reduction and oxidation of the olefin of the natural sesquiterpene, allowed obtaining a series of derivatives which displayed mild antifungic activities and did not show cytotoxic activities toward certain human tumor cell lines.

Keywords : Xanthorrhizol; Iostephane heterophylla; antifungic agents; bisabolene derivatives.

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