Abstract

HERNANDEZ-GALLEGOS, Zurisaddai  and  PEREZ-ALVAREZ, Víctor. Un estudio cuantitativo de la relación estructura-actividad de una serie de N-[2-(dimetilamino)etil]acridina-4-carboxamidas con actividad citotóxica. Rev. Soc. Quím. Méx [online]. 2002, vol.46, n.3, pp.223-226. ISSN 0583-7693.

The Hansch analysis was applied to a series of N-[2-(dimethylamino)ethyl] acridine-4-carboxamide analogues with cytotoxic activity. The results showed a significant relationship between the cytotoxicity of the compounds and the size and the delocalizating positive charge of the substituents. A parabolic dependence of cytotoxic activity was observed with the width of substituents in 5-position, while for substituents in the 6-position and 7-position steric hindrance was found.

Keywords : Structure-activity; acridines; cytotoxic activity; QSAR.