Abstract

NAVARRETE, Andrés; FLORES, Alejandro; SIXTOS, Carmen  and  REYES, Benito. Análisis isobolográfico de la interacción entre α-sanshool, sesamina, asarinina, fagaramida y piperina sobre la actividad larvicida en Culex quinquefasciatus Say. Rev. Soc. Quím. Méx [online]. 2003, vol.47, n.2, pp.178-185. ISSN 0583-7693.

An isobolographic analysis of larvicidal interactions between α-sanshool with sesamin, asarinin, fagaramide and piperine on Culex quinquefasciatus was performed. α-Sanshool was the most active compound (LC₅₀ =3.97 ± 0.61 ppm) followed by fagaramide (LC₅₀ = 7.92 ± 1.22 ppm), piperine (LC₅₀ = 10.02 ± 2.44 ppm), asarinin (LC₅₀ = 69.95 ± 15.00 ppm) and sesamin (LC₅₀ = 277.4 ± 35.75 ppm). Synergistic interaction between α-sanshool and sesamin or asarinin was observed, whereas with fagaramide or piperine produced an additive effect.

Keywords : Isobolographic analysis; larvicidal activity; α-sanshool; sesamin; asarinin; fagaramide; piperine; Culex quinquefasciatus.