Abstract

MUNOZ-ZURITA, Alejandro et al. Síntesis y evaluación del efecto ansiolítico de un nuevo derivado pirimido[1,6-a]pirimidínico. Rev. Soc. Quím. Méx [online]. 2003, vol.47, n.4, pp.298-302. ISSN 0583-7693.

The synthesis of (E)-6,8-dioxo-7-propyl-9-styrylcarboxamido-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,6-a]pyrimidine (9) from 6-aminouracil (4) using a chemo- and regioselective pathway is described herein. Additionally we report the pharmacobiological evaluation of the compound 9 using the anxiolitic test plus maze elevator and the effect of 9 over the locomotor activity in the Wistar rats. The results suggest that compound 9 exhibit a significant anxiolitic activity with considerable motor depression.

Keywords : Adenosine receptors antagonist; chemoselectivity; anxiety; locomotion; anxiolitic experimental model.

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