Abstract

DIAZ-ACOSTA, Alondra E.  and  MEMBRILLO-HERNANDEZ, Jorge. Psycological consequenses of protein oxidation by carbonylation in different biological models. TIP [online]. 2006, vol.9, n.1, pp.34-44. ISSN 1405-888X.

Production of Reactive Oxygen Species (ROS) is an unavoidable consequence of the aerobic metabolism. Due to the accumulating experimental data relating protein oxidation to cell processes such as ageing and diverse human diseases, research in this area has been greatly increased. Proteins undergo different types of oxidative modifications, in particular, the formation of carbonyl groups, has been extensively used in the studies focused on the determination of the extent of protein damage. Despite the fact that the mechanisms linking protein oxidation and cellular processes such as proteólisis, apoptosis or reproduction have yet to be elucidated, we are close to understand the role of protein oxidation in cell physiology.

Keywords : Ageing; Reactive Oxygen Species; oxidative stress; oxidation; proteolisis.

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