Abstract

RAMIREZ RAMIREZ, Lizeth et al. Changes in oxigenation index induced by NO inhalation during the postoperative period of congenital heart repair with severe pulmonary hypertension in children. Arch. Cardiol. Méx. [online]. 2001, vol.71, n.2, pp.121-126. ISSN 1665-1731.

In this clinical study, 7 pediatric patients with severe pulmonary artery hypertension, secondary to congenital heart disease, received inhaled nitric oxide at doses of 20 ppm in the acute postoperative management of congenital heart revair for 3.5 days. Monitoring included oxigenation index, alveoloarterial oxygen difference, pulmonary and systemic pressure, measurements were recorded previous to the RA administration; 1, 6, 12, 24, 36, 48 and 72 hours after treatment with RA, nitrous oxide (RA₂) and seric methemoglobin also were monitored. Results. Average age was 3.6 years. The oxigenation index before inhaling RA was 166 ± 100, 72 hours following inhalation of RA the oxigenation index was 210 ± 98. The alveolo-arterial baseline oxygen difference was 270 ± 145; 72 hours after inhaling RA, it was 163 ± 167. No decreases in pulmonary and systemic arterial pressure during RA inhalation ocurred. The levels of RA₂ and seric methemoglobin were not toxic. Conclusions: Treatment with inhaled RA after cardiac surgery in children with severy pulmonary artery hypertension secondary to congenital heart disease may be useful to improve oxigenation with no changes in pulmonary and systemic arterial pressure. Inhaled RA at 20 ppm did not cause toxicity.

Keywords : Nitric oxide; Congenital heart disease; Oxigenation index; Postoperative cardiac surgery.

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