Abstract

HERNANDEZ-PACHECO, Guadalupe et al. Genetic study of the vasovagal syncope associated to the Arg389Gly polymorphism of the B1 adrenergic receptor. Arch. Cardiol. Méx. [online]. 2008, vol.78, n.2, pp.134-138. ISSN 1665-1731.

The purpose of this study was to evaluate the correlation between the vasovagal syncope (VVS) and the B1 adrenergic receptor polymorphism at the 389 position. Seventy individuals with VVS were selected. DNA was extracted from peripheral blood by salting out and subjected to the amplification-restriction test. Genotype identification was made by polyacrylamide gel electrophoresis. A higher frequency in genotype and alíele frequencies were found in individuals with positive tilted table test respect individuals with negative test, as well as a marked preference of the GlyGly phenotype in women. Genotype Arg389Gly was the most frequent between individuals with positive response in passive phase with respect to those in the induced phase. When the genotype was analyzed based on the hemodynamic response (VASIS) a gradient is observed in the frequency of Arg389Gly with the highest major frequency in the cardio-inhibitory response followed by the mixed response, and finally the vasodepressor response. These results suggest that the SVV has a genetic component associated with the Arg389Gly polymorphism of the adrenergic receptor. The Gly alíele has a high risk association and it is maintained in the population through heterozygosis.

Keywords : Syncope; Polymorphism; B1 adrenergic receptor; Risk genotype.

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