Abstract

NAGAY HERNANDEZ, Sandra et al. Influence of rosuvastaitn in endothelial function and oxidative stress, in patients with acute coronary syndrome. Arch. Cardiol. Méx. [online]. 2008, vol.78, n.4, pp.379-383. ISSN 1665-1731.

Purpose: The endothelial function is the cornerstone of several cardiovascular disease. In this trial we compared how the Nitric Oxide (NO) and Oxidative Stress (OS) serum levels, as surrogate markers of endothelial function, change in patients who received (or not) rosuvastatin during the first seven days of an acute coronary syndrome (ACS). Methods: Twenty-two patients with ACS (age:66 ± 9 years, gender: ten female and 12 male) were randomized in two groups. Patients in the first group (G1) received the conventional treatment for an ACS, plus placebo. The other group (G2) additionally received a daily oral dose of 40 mg of rosuvastatin. We measured the blood levels of nitrates and OS in both groups twice: at baseline (admission to Intensive care unit) and seven days after. The statistical analysis was performed using the paired t-test orthe Chi² test depending of the variables. Statistical significance was considered with a p < 0.05. Results: Groups (G1 and G2) differed statistically on age (G1 = 71 years ± 10 vs G2 63 ± 9 years, p = 0.04). After 7 days of the ACS onset, ON levels diminished on 21% (p = 0.17) in G1, but raised on 24% in the group who received rosuvastatin (p = 0.005), with statistically difference between groups (p = 0.005). On the other hand, the OS, augmented statistically on both groups: G1 (17%, p < 0.001) and G2 (13%, p < 0.001), without any difference between groups (p = 0.77). Conclusion: The endothelial dysfunction in the first days of an ACS is accentuated, but with the use of rosuvastatina, the endothelial function improves. In contrast, the OS increase in both groups, without differences between groups.

Keywords : Statins; Nitric oxide; Oxidative stress; Myocardial infarction; Acute coronary syndrome; Endothelial function.

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