Abstract

ROLDAN-GOMEZ, Francisco Javier; PAVON-MARTINEZ, Natalia; GALVEZ-PEREZ, Faustino  and  VARGAS-BARRON, Jesús. Inhibiting contractility without necrosis: Would it be helpful for hypertrophic cardiomyopathy? Experimental model of intramyocardial botulinum toxin and wortmannin. Arch. Cardiol. Méx. [online]. 2012, vol.82, n.4, pp.320-323. ISSN 1665-1731.  https://doi.org/10.1016/j.acmx.2012.06.007.

The purpose of this paper is to introduce a new idea: local inhibition of contractility without necrosis. It's potential usefulness in hypertrophic cardiomyopathy treatment is discussed and 2 pharmacological models, administrating botulinum toxin and wortmannin directly in the myocardium are disclosed.

Keywords : Hypertrophic cardiomyopathy; Intramyocardial administration; Botulinum toxin; Wortmannin; Mexico.