Abstract

VARGAS-GONZALEZ, Alvaro. Proliferation of adult mammalian ventricular cardiomyocytes: A sporadic but feasible phenomenon. Arch. Cardiol. Méx. [online]. 2014, vol.84, n.2, pp.102-109. ISSN 1665-1731.  https://doi.org/10.1016/j.acmx.2014.01.002.

Proliferation of adult mammalian ventricular cardiomyocytes has been ruled out by some researchers, who have argued that these cells are terminally differentiated; however, this dogma has been rejected because other researchers have reported that these cells can present the processes necessary to proliferate, that is, DNA synthesis, mitosis and cytokinesis when the heart is damaged experimentally through pharmacological and surgical strategies or due to pathological conditions concerning the cardiovascular system. This review integrates some of the available works in the literature evaluating the DNA synthesis, mitosis and cytokinesis in these myocytes, when the myocardium is damaged, with the purpose of knowing if their proliferation can be considered as a feasible phenomenon. The review is concluded with a reflection about the perspectives of the knowledge generated in this area.

Keywords : Ventricular cardiomyocytes; Adult stage; DNA synthesis; Mitosis; Cytokinesis and dedifferentiation; Proliferation; Mexico.

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