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Archivos de cardiología de México
On-line version ISSN 1665-1731Print version ISSN 1405-9940
Abstract
PARRA-BRAVO, J. Rafael et al. B-type brain natriuretic peptide as marker of hemodynamic overload of the patent ductus arteriosus in the preterm infant. Arch. Cardiol. Méx. [online]. 2021, vol.91, n.1, pp.17-24. Epub Mar 09, 2021. ISSN 1665-1731. https://doi.org/10.24875/acm.19000398.
Introduction:
The echocardiogram is the gold standard, in the diagnosis of the hemodynamically significant patent ductus arteriosus (hs-PDA) of the premature newborn (PNB). Type B natriuretic peptide (BNP) may be useful in the diagnosis and management of CAP-hs.
Objective:
To assess the utility of BNP as a marker of hemodynamic overload of the patent ductus arteriosus in newborns with gestational age < 32 weeks or weight < 1500 grams, and to identify the best cut-off point for BNP levels that would best predict a PDA with hemodynamic impact requiring pharmacological and/or surgical treatment.
Methods:
Retrospective, observational and descriptive study of PNB < 32 weeks gestation or weight < 1500 grams, in which echocardiogram and BNP determination was performed. Analysis of the global sample and by subgroups, depending on the hs-PDA status was performed.
Results:
A total of 29 patients were analyzed. A significant correlation was found between the PDA/weight ratio and BNP levels (Spearman: 0.71; 95% confidence interval: 0.45-0.87; p < 0.001). The best BNP cut-off point to predict CAP-hs was 486.5 pg/ml with a sensitivity of 81% and specificity of 92% (p < 0.001).
Conclusion:
The BNP cut-off point identified in the present study was correlated with the presence of CAP-hs.
Keywords : Patent ductus arteriosus; México; B-type natriuretic peptide; Prematurity.