Abstract

MUNOZ-HERNANDEZ, María Rocío; SANTOS-PRECIADO, José Ignacio  and  PAVIA-RUZ, Noris. Fat redistribution and metabolic disturbances in HlV-infected children and adolescents with highly active antiretroviral therapy. Bol. Med. Hosp. Infant. Mex. [online]. 2009, vol.66, n.4, pp.343-349. ISSN 1665-1146.

Introduction. Morbidity and mortality associated with human immunodeficiency virus (HIV) infection has decreased since the introduction of highly active antiretroviral therapy. Unfortunately, treatment has been associated with metabolic disorders, lipodystrophy syndrome (LDS) characterized by loss of fat, dyslipidemia and glucose intolerance. This study was conducted in a pediatric outpatient clinic and included children and adolescents infected with HIV/acquired immunodeficiency syndrome (AIDS) aged from 2 to 18 years. Methods. Total cholesterol, triglycerides and fasting glucose were measured. Patients were evaluated based on characteristics associated with LDS. Results. Ninety two children and adolescents infected with HIV were included; 51% of patients had hyperlipidemia and 16% showed evidence of fat redistribution. A significant percentage (54%) of HIV-infected children and adolescents developed changes in metabolic parameters or fat redistribution. Hypertriglyceridemia and peripheral lipoatrophy were the most frequent alterations. Conclusions. Although widely described in adults infected with HIV, reports of LDS in children are rare. Future research lines in children and adolescents infected with HIV/AIDS may determine the therapeutic strategies for the management of LDS in children.

Keywords : HIV; infection; child; cholesterol; triglycerides; lipodystrophy.

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