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Boletín médico del Hospital Infantil de México
Print version ISSN 1665-1146
Abstract
MEDEIROS, Mara et al. Prevalence of kidney disease in asymptomatic children with family history of renal replacement therapy. Bol. Med. Hosp. Infant. Mex. [online]. 2015, vol.72, n.4, pp.257-261. ISSN 1665-1146. https://doi.org/10.1016/j.bmhimx.2015.07.004.
Background:
Having a first- or second-degree relative with chronic kidney disease (CKD) has been reported as a risk factor for CKD development. The aim of the study was to determine the prevalence of CKD in children with a first- or second-degree relative undergoing renal replacement therapy (hemodialysis or renal transplant).
Methods:
A screening study was performed in asymptomatic children with a family history of CKD in a first- or second-degree relative undergoing renal replacement therapy. Informed consent was obtained in all cases. A clinical examination was performed. Blood and urine samples were obtained for serum creatinine, serum electrolytes, urinalysis, and microalbumin/creatinine ratio.
Results:
There were 45 subjects included with a median age of 9.6 years; 24 (53%) were male. Urinary abnormality/CKD was observed in 11 subjects (24.4%). The most common urinary abnormalities were hematuria (6/11) and microalbuminuria (4/11). Stage 2 CKD was found in seven subjects and four subjects with stage 1 CKD.
Conclusions:
The study of families of patients undergoing renal replacement therapy is useful to identify children in early stages of kidney disease.
Keywords : CKD screening; Risk factor; Children; Hematuria.
