Abstract

MARTEL-ESTRADA, S.A.; OLIVAS-ARMENDARIZ, I.; MARTINEZ-PEREZ, C.A.  and  CHACON-NAVA, J.G.. In vitro bioactivity of chitosan/poly(dl-lactide) composites. Rev. Mex. Ing. Quím [online]. 2012, vol.11, n.3, pp.505-512. ISSN 1665-2738.

Porous composites scaffolds of different concentration of chitosan/ Poly(DL,lactide) were fabricated for tissue engineering applications by thermally induced phase separation and lyophilization techniques. The in vitro bioactivity evaluation of the scaffolds was carried out by analyzing the apatite layers produced on them using Simulated Body Fluid (SBF) as incubation medium. The interaction betwern functional groups in the composite was analyzed using differential scanning calorimetry. The apatite formation wat analyzed using FTIR spectroscopy, Field Emission Scanning Electron Microscopy coupled to energy-dispersive electron X-ray spectroscopy and X-ray diffraction. The cumulative results obtained from IR spectra and SEM-EDS, suggest that the developed composites might have potential applications in tissue engineering.

Keywords : chitosan; poly(DL-lactide); apatite; bioactivity; thermally induced phase separation.